During printing or updating of a book, you get a message that one or more color definitions are inconsistent.
When you update a book, Frame takes a look at the colors in the first file and compares the rest of the files to it. When Frame detects certain differences, it will issue this error.
A file has one or more colors than other files in the book. The solution is to either import that file's colors into the rest of the book, or to delete the unneeded colors from the file(s) that contain them. I prefer the latter approach, only because I like myfiles to be as bare-boned as possible.
A file has a color defined differently. Every color has a specific definition: it has a name, a mix of certain percents of CMYK or RGB, and so on as you see in the Define Color dialog. But a color also has print settings associated with it, such as the screen angle, and whether it prints as a spot color, a separation, or not at all.
In this fix, you copy the colors from a good file into the rest of the book.
If that does not fix it, then the problem may have been that the screen angle or separatoin/spot settings are different. Try these steps. In this fix you print a PostScript file with separations.
Hopefully that will fix it.